Hydroxychloroquinine updates (and other potential treatments)

[MU82]

From the NYT:

As the coronavirus tears across much of Texas, Dr. Esmaeil Porsa is grappling with one of the most formidable challenges he has faced: The Houston hospital system he operates is running out of vaccines.

Porsa, the CEO of Harris Health System, which treats thousands of mostly uninsured patients, warned Friday that its entire vaccine supply could be depleted by midday Saturday. The problem is not one of capability – the vaccination centers he oversees have easily been administering as many as 2,000 vaccines a day – but of availability.

"All of a sudden the distribution of vaccines stopped," Porsa said. "It's perplexing and frustrating because I keep hearing that there are high percentages of vaccines that have been distributed but not administered."

In the midst of one of the deadliest phases of the pandemic in the United States, health officials in Texas and around the country are growing desperate, unable to get clear answers as to why the long-anticipated vaccines are suddenly in short supply. Inoculation sites are canceling thousands of appointments in one state after another as the nation's vaccines roll out through a bewildering patchwork of distribution networks, with local officials uncertain about what supplies they will have in hand.

[Jockey]

From the NYT:

As the coronavirus tears across much of Texas, Dr. Esmaeil Porsa is grappling with one of the most formidable challenges he has faced: The Houston hospital system he operates is running out of vaccines.

Porsa, the CEO of Harris Health System, which treats thousands of mostly uninsured patients, warned Friday that its entire vaccine supply could be depleted by midday Saturday. The problem is not one of capability – the vaccination centers he oversees have easily been administering as many as 2,000 vaccines a day – but of availability.

"All of a sudden the distribution of vaccines stopped," Porsa said. "It's perplexing and frustrating because I keep hearing that there are high percentages of vaccines that have been distributed but not administered."

In the midst of one of the deadliest phases of the pandemic in the United States, health officials in Texas and around the country are growing desperate, unable to get clear answers as to why the long-anticipated vaccines are suddenly in short supply. Inoculation sites are canceling thousands of appointments in one state after another as the nation's vaccines roll out through a bewildering patchwork of distribution networks, with local officials uncertain about what supplies they will have in hand.

While we finally have a competent team ready to roll out the vaccine, we are still suffering from the insane incompetency of the previous regime. It will be extremely hard to vaccinate 100 Million in 100 days when we don't have supplies  of the vaccine. Sadly, several of us wrote about these problems months ago - we knew it was coming thanks to Bunker Boy and his supporters.

[cheebs09]

While we finally have a competent team ready to roll out the vaccine, we are still suffering from the insane incompetency of the previous regime. It will be extremely hard to vaccinate 100 Million in 100 days when we don't have supplies  of the vaccine. Sadly, several of us wrote about these problems months ago - we knew it was coming thanks to Bunker Boy and his supporters.

Aren't we already at 1M per day? Is it jus that we will exhaust the initial supply that we won't keep it going?

[The Sultan]

Aren't we already at 1M per day? Is it jus that we will exhaust the initial supply that we won't keep it going?

We are over 1M per day and it will likely not decrease.  The shortages are mostly about states opening up who is eligible and not having enough to meet the increased demand.

[forgetful]

We are over 1M per day and it will likely not decrease.  The shortages are mostly about states opening up who is eligible and not having enough to meet the increased demand.

Your statements are mutually incompatible. We cannot keep up the current pace without a supply increase. We have shortages because of a lack of supply. Many states are cancelling previously scheduled appointments, because there are no vaccines available.

There is no indication we will observe a supply increase, rather we are likely to observe a decline without serious intervention. Pfizer has already indicated they will ship fewer vials than originally agreed upon.

We saw a ramp-up to the current over 1M per day, because the US government released all supplies immediately (while hiding this fact from everyone involved). That means, no more stockpile, and a wait on a supply that we are apparently uncertain on.

[Hards Alumni]

Your statements are mutually incompatible. We cannot keep up the current pace without a supply increase. We have shortages because of a lack of supply. Many states are cancelling previously scheduled appointments, because there are no vaccines available.

There is no indication we will observe a supply increase, rather we are likely to observe a decline without serious intervention. Pfizer has already indicated they will ship fewer vials than originally agreed upon.

We saw a ramp-up to the current over 1M per day, because the US government released all supplies immediately (while hiding this fact from everyone involved). That means, no more stockpile, and a wait on a supply that we are apparently uncertain on.

Except J&J and AZ will be ready to ship as soon as they get emergency approval. 

[jesmu84]

Except J&J and AZ will be ready to ship as soon as they get emergency approval.

I thought J &J stopped their trials?

[Frenns Liquor Depot]

I thought J &J stopped their trials?

No Merck and another company.

[tower912]

J&J are chomping at the bit.

[forgetful]

Except J&J and AZ will be ready to ship as soon as they get emergency approval.

J&J will be a month before shots in arms, AZ longer. That will be essentially half-way through the 100-day goal. Also, J&J announced delays in production, which will slow its release.

Moderna, may need to shift some production to booster shots against the new variants.

The 100-million shots in arms is more challenging than most people think. Remember, they originally wanted 20-million shots in arms by the end of December. That was with 20-million doses ready to be delivered immediately. They got 2-million administered.

I'm hopeful that the supply will be there, but it is far from a sure thing.

[pbiflyer]

Oklahoma trying to return its $2m stockpile of hydroxychloroquine

https://www.readfrontier.org/stories/oklahoma-trying-to-return-its-2m-stockpile-of-hydroxychloroquine/

Why would they want to return the miracle drug that people here said is so effective?

[TSmith34, Inc.]

They can send it to rocket, he still thinks it works.

Who could have guessed that making a medical decision based on trying to curry favor with a science denying politician would turn out poorly?

[jesmu84]

Why not give it out to needy patients with diseases treated with it like lupus?

[GooooMarquette]

Why not give it out to needy patients with diseases treated with it like lupus?

Because that would make WAY too much sense.

[Galway Eagle]

Why not give it out to needy patients with diseases treated with it like lupus?

Because WeLfArE sTaTe and SoCiAlIsM

[pbiflyer]

Why not give it out to needy patients with diseases treated with it like lupus?

Slippery slope that leads dangerously down a path of government providing valuable services to its taxpayers. Today it's medicine, tomorrow the citizenry is going to want to properly fund schools. Where does it ever end?!? Repairing roads and bridges? Dogs and cats sleeping together?

[MU82]

Y'all are ticklin' my funny bone!

[Frenns Liquor Depot]

Potential new antiviral in pill form.

https://www.wsj.com/articles/covid-19-pill-shows-promise-in-preliminary-testing-11615006861

[TSmith34, Inc.]

Potential new antiviral in pill form.

https://www.wsj.com/articles/covid-19-pill-shows-promise-in-preliminary-testing-11615006861

That would be a great addition to the arsenal if it proves out.

Thanks for posting.

[pbiflyer]

One year ago today, the medical world ignored a brilliant and easy solution to the epidemic.

https://www.politico.com/news/2021/04/23/trump-bleach-one-year-484399

"A question that probably some of you are thinking of if you're totally into that world. So, supposing we hit the body with a tremendous — whether it's ultraviolet or just very powerful light — and I think you said that that hasn't been checked, but you're going to test it. And then I said, supposing you brought the light inside the body, which you can do either through the skin or in some other way, and I think you said you're going to test that, too. It sounds interesting. And then I see the disinfectant, where it knocks it out in a minute. One minute. And is there a way we can do something like that, by injection inside or almost a cleaning. Because you see it gets in the lungs, and it does a tremendous number on the lungs. So it would be interesting to check that."

[Jockey]

A true genius is almost always misunderstood. 

[tower912]

Injecting bleach in honor of the one year anniversary.

[cheebs09]

One year ago today, the medical world ignored a brilliant and easy solution to the epidemic.

https://www.politico.com/news/2021/04/23/trump-bleach-one-year-484399

"A question that probably some of you are thinking of if you're totally into that world. So, supposing we hit the body with a tremendous — whether it's ultraviolet or just very powerful light — and I think you said that that hasn't been checked, but you're going to test it. And then I said, supposing you brought the light inside the body, which you can do either through the skin or in some other way, and I think you said you're going to test that, too. It sounds interesting. And then I see the disinfectant, where it knocks it out in a minute. One minute. And is there a way we can do something like that, by injection inside or almost a cleaning. Because you see it gets in the lungs, and it does a tremendous number on the lungs. So it would be interesting to check that."

Incredible that it's been a year already for some of this stuff. I honestly thought the bleach comment was a little later in the game.

[MU82]

Just being "sarcastic" ... while looking completely straight-faced at Birx.

[Billy Hoyle]

It seems after the lab leak issue there's another "Trump may have been right" push, this time with Hydroxychloroquine. Thoughts?

https://www.news-medical.net/amp/news/20210602/HydroxychloroquineAzithromycin-therapy-at-a-higher-dose-improved-survival-by-nearly-20025-in-ventilated-COVID-patients.aspx