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Author Topic: Vaccine/Antibody updates  (Read 357184 times)

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #275 on: July 30, 2020, 07:23:21 PM »
Russia set to approve Covid vaccine, even though the study is still in the midst of phase 2 studies. Frightening…

https://thehill.com/policy/international/509496-russia-aiming-to-approve-covid-19-vaccine-within-weeks-report

Russia’s vaccine still needs to finish its second phase of testing, which officials say they expect to complete by Aug. 3. Then, the third phase of testing will be conducted at the same time that front-line health care workers are vaccinated, according to the network.


——————-

The Russians are calling this a “Sputnik moment,“ but it also has the very real potential to be more like Chernobyl.

forgetful

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Re: Vaccine/Antibody updates
« Reply #276 on: July 30, 2020, 07:42:27 PM »
Russia set to approve Covid vaccine, even though the study is still in the midst of phase 2 studies. Frightening…

https://thehill.com/policy/international/509496-russia-aiming-to-approve-covid-19-vaccine-within-weeks-report

Russia’s vaccine still needs to finish its second phase of testing, which officials say they expect to complete by Aug. 3. Then, the third phase of testing will be conducted at the same time that front-line health care workers are vaccinated, according to the network.


——————-

The Russians are calling this a “Sputnik moment,“ but it also has the very real potential to be more like Chernobyl.

China has already been vaccinating their military too.

Too bad we can't see transparent results on what happen in each of these experiments.

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #277 on: July 30, 2020, 08:02:25 PM »
China has already been vaccinating their military too.

Too bad we can't see transparent results on what happen in each of these experiments.


Yep. Whatever information they do release will almost certainly be sanitized...especially since they're going to be vaccinating their general public soon.

Frenns Liquor Depot

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Re: Vaccine/Antibody updates
« Reply #278 on: July 31, 2020, 05:34:18 PM »
Here is a follow up to my post about med profs saying that we should not necessarily be concerned about falling antibody counts.  This is written by a virologist at Yale who has been putting out a lot of very interesting studies on covid. 

It’s an opinion piece but I found also very informative to a layperson like me. 

https://www.nytimes.com/2020/07/31/opinion/coronavirus-antibodies-immunity.html

MU Fan in Connecticut

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Re: Vaccine/Antibody updates
« Reply #279 on: August 01, 2020, 07:03:04 AM »
Here is a follow up to my post about med profs saying that we should not necessarily be concerned about falling antibody counts.  This is written by a virologist at Yale who has been putting out a lot of very interesting studies on covid. 

It’s an opinion piece but I found also very informative to a layperson like me. 

https://www.nytimes.com/2020/07/31/opinion/coronavirus-antibodies-immunity.html

Estimates of only 43% to 66%, not 90%, needed to be vaccinated to protect the unvaccinated.

forgetful

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Re: Vaccine/Antibody updates
« Reply #280 on: August 01, 2020, 07:31:21 AM »
Estimates of only 43% to 66%, not 90%, needed to be vaccinated to protect the unvaccinated.

That has generally been the benchmark numbers. It is a very simple calculation for the approximation. You take the R0 value and plug it into 1- 1/R0 to get the fraction of the population needed to reach "herd immunity".

Estimates of the R0 without any quarantine measures, or any other restrictions range from 1.8-3. That gives you a range of 44-66%. That value can be achieved by a combination of immunity from both actual infections and vaccines.


Big Papi

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Re: Vaccine/Antibody updates
« Reply #281 on: August 01, 2020, 09:20:58 AM »
Here is a follow up to my post about med profs saying that we should not necessarily be concerned about falling antibody counts.  This is written by a virologist at Yale who has been putting out a lot of very interesting studies on covid. 

It’s an opinion piece but I found also very informative to a layperson like me. 

https://www.nytimes.com/2020/07/31/opinion/coronavirus-antibodies-immunity.html


https://www.yahoo.com/news/dont-panic-waning-coronavirus-immunity-124700728.html

https://keyt.com/health/2020/08/02/do-some-people-have-protection-against-the-coronavirus/



« Last Edit: August 02, 2020, 05:47:40 PM by mufanatic »

Jockey

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Re: Vaccine/Antibody updates
« Reply #282 on: August 06, 2020, 02:15:20 PM »
AP poll shows that only 42% will get vaccine when made available.

If the vaccines is (optimistically) 60-70% effective, that is nowhere near enough for herd immunity.

Vaccines do not cure viruses. Vaccinations do

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #283 on: August 06, 2020, 02:49:58 PM »
AP poll shows that only 42% will get vaccine when made available.

If the vaccines is (optimistically) 60-70% effective, that is nowhere near enough for herd immunity.

Vaccines do not cure viruses. Vaccinations do


IMHO, the low rate is a direct result of POTUS' history of forcing Executive Branch agencies to do exactly what he wants...regardless of their oath to the Constitution, and regardless of their professional expertise and ethics. For Exhibit A, I give you the CDC school reopening plan - released, then withdrawn and watered down.
I would not put it past him to exert the same kind of influence over FDA's vaccine review process. The poll seems to indicate that many others feel the same way.

Personally, I will only take a vaccine that has been approved by FDA plus either the EU or UK regulatory agency.

Frenns Liquor Depot

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Re: Vaccine/Antibody updates
« Reply #284 on: August 06, 2020, 03:10:44 PM »
One thing I will look for is whether or not Fauci endorses it.  If we get word salad from him I would wait

Jockey

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Re: Vaccine/Antibody updates
« Reply #285 on: August 06, 2020, 03:15:18 PM »
One thing I will look for is whether or not Fauci endorses it.  If we get word salad from him I would wait

Exactly my feelings. And if Biden is elected, my decision will STILL be based on the recommendations of experts.

Frenns Liquor Depot

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Re: Vaccine/Antibody updates
« Reply #286 on: August 13, 2020, 08:55:07 AM »
New pre-print study showing 70% keep antibodies 6 months after infection.  Good news potentially on the durability of immunity question.   

https://www.medrxiv.org/content/10.1101/2020.07.21.20159178v1

https://twitter.com/florian_krammer/status/1293903501765074944?s=21
« Last Edit: August 13, 2020, 08:57:33 AM by Frenns Liquor Depot »

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #287 on: September 04, 2020, 09:11:48 AM »
NPR: Operation Warp Speed Top Adviser On The Status Of A Coronavirus Vaccine

https://www.npr.org/2020/09/03/909312697/operation-warp-speed-top-adviser-on-the-status-of-a-coronavirus-vaccine

It's a recorded interview with transcript, but here are the key points:

* It is "possible but very unlikely" that a vaccine will be ready by October or November

* If the Pfizer or Moderna vaccine is approved, we may have limited supply of approved vaccine for 70+ and first responders "by the end of the year."

* If the Pfizer or Moderna vaccine is approved, we may have enough for general population by "the middle of 2021."

Bottom line: For the vast majority of us, the social distancing, mask-wearing, risk balancing life of COVID will likely be with us for about another year...and that's if we are fortunate enough to have one of the vaccines bankrolled by the US pan out.

WEAR A MASK IN PUBLIC, AND STAY AWAY FROM CROWDED, HIGH-RISK SITUATIONS WHENEVER POSSIBLE

shoothoops

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Re: Vaccine/Antibody updates
« Reply #288 on: September 06, 2020, 08:57:32 PM »
Getting charged $10,984 for an $8 antibody test...


https://twitter.com/propublica/status/1302185399121588224?s=19

jesmu84

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Re: Vaccine/Antibody updates
« Reply #289 on: September 06, 2020, 10:36:23 PM »
Getting charged $10,984 for an $8 antibody test...


https://twitter.com/propublica/status/1302185399121588224?s=19

Best healthcare system in the world!

MU Fan in Connecticut

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Re: Vaccine/Antibody updates
« Reply #290 on: September 08, 2020, 08:30:01 PM »
I see there is a story that Aztra Zeneca is putting their Phase 3 vaccine trial on hold to study a patient who had adverse reaction.

ZiggysFryBoy

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Re: Vaccine/Antibody updates
« Reply #291 on: September 08, 2020, 08:50:44 PM »
I see there is a story that Aztra Zeneca is putting their Phase 3 vaccine trial on hold to study a patient who had adverse reaction.

1 person in the UK had an adverse reaction, so AZ is stopping their trial.

UW@Madison was involved in the study.

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #292 on: September 08, 2020, 08:53:46 PM »
I see there is a story that Aztra Zeneca is putting their Phase 3 vaccine trial on hold to study a patient who had adverse reaction.


Yep, and this is of the most promising vaccines. No detail so far on what the reaction was, but it sounds like the participant will survive. Hopefully they quickly determine that it was unrelated to the vaccine, so they can resume without too much delay.

This is why they need to fully complete and analyze the phase 3 trials before the FDA approves anything. They did not see this type of reaction in the phase 1 or phase 2 trials, and a phase 3 trial is often the first time officials learn of a significant reaction to an investigational drug.

https://www.usatoday.com/story/news/health/2020/09/08/report-covid-vaccine-candidate-created-oxford-university-and-astrazeneca-put-hold/5752569002/

forgetful

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Re: Vaccine/Antibody updates
« Reply #293 on: September 08, 2020, 10:10:36 PM »

Yep, and this is of the most promising vaccines. No detail so far on what the reaction was, but it sounds like the participant will survive. Hopefully they quickly determine that it was unrelated to the vaccine, so they can resume without too much delay.

This is why they need to fully complete and analyze the phase 3 trials before the FDA approves anything. They did not see this type of reaction in the phase 1 or phase 2 trials, and a phase 3 trial is often the first time officials learn of a significant reaction to an investigational drug.

https://www.usatoday.com/story/news/health/2020/09/08/report-covid-vaccine-candidate-created-oxford-university-and-astrazeneca-put-hold/5752569002/

Also a good example of why the phase 3 trials can take a long time. An adverse reaction, a death, and everything gets shut down until they can be 100% certain it was not related to the drug/vaccine.

pacearrow02

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Re: Vaccine/Antibody updates
« Reply #294 on: September 08, 2020, 10:14:00 PM »
Also a good example of why the phase 3 trials can take a long time. An adverse reaction, a death, and everything gets shut down until they can be 100% certain it was not related to the drug/vaccine.

Hey forgetful...maybe you missed it in the Covid thread, was wondering what your thoughts were on the Sturgis study?  Whether we should take it seriously or not?

MU Fan in Connecticut

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Re: Vaccine/Antibody updates
« Reply #295 on: September 11, 2020, 01:51:54 PM »
A little insight to the COVID-19 vaccine development at Pfizer.


Pfizer’s CT site helped develop a COVID-19 vaccine. But will it work?
By Ana Radelat, CTMirror.org Updated 9:48 am EDT, Wednesday, September 9, 2020

https://www.nhregister.com/news/coronavirus/article/Pfizer-s-CT-site-helped-develop-a-COVID-19-15553337.php


tower912

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Re: Vaccine/Antibody updates
« Reply #296 on: September 15, 2020, 07:38:33 AM »
https://www.pittwire.pitt.edu/news/pitt-scientists-discover-tiny-antibody-component-highly-effective-preventing-and-treating-sars

Pitt has been sciencing their asses off since the beginning of this.   It sure would be helpful if this is shown to be effective in humans. 
Luke 6:45   ...A good man produces goodness from the good in his heart; an evil man produces evil out of his store of evil.   Each man speaks from his heart's abundance...

It is better to be fearless and cheerful than cheerless and fearful.

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #297 on: September 15, 2020, 08:28:52 AM »
https://www.pittwire.pitt.edu/news/pitt-scientists-discover-tiny-antibody-component-highly-effective-preventing-and-treating-sars

Pitt has been sciencing their asses off since the beginning of this.   It sure would be helpful if this is shown to be effective in humans.


The science makes sense - really hope it works out in clinical trials. Pitt has some top-notch researchers.

GooooMarquette

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Re: Vaccine/Antibody updates
« Reply #298 on: September 15, 2020, 03:06:14 PM »
NIH closely evaluating the adverse event in the Astra Zeneca trial...but A-Z is not being very forthcoming. Glad to see NIH is pressing them on this serious event, and disappointed that A-Z is being so evasive. I hope NIH keeps the pressure on, and only gives the green light if and when satisfactory answers are provided.

NIH is ‘very concerned’ about serious side effect in coronavirus vaccine trial

https://www.latimes.com/science/story/2020-09-15/nih-concerned-side-effect-in-astrazeneca-coronavirus-vaccine-trial

“The highest levels of NIH are very concerned,” said Dr. Avindra Nath, intramural clinical director and a leader of viral research at the National Institute for Neurological Disorders and Stroke, a division of the NIH. “Everyone’s hopes are on a vaccine, and if you have a major complication the whole thing could get derailed.”

A great deal of uncertainty remains about what happened to the unnamed patient. AstraZeneca said the trial volunteer recovered from a severe inflammation of the spinal cord and is no longer hospitalized.

Nath and another neurologist said they understood that the patient was afflicted with transverse myelitis, though the company has not confirmed this. Transverse myelitis produces symptoms involving inflammation along the spinal cord that can cause pain, muscle weakness and paralysis.

AstraZeneca “need to be more forthcoming with a potential complication of a vaccine which will eventually be given to millions of people,” Nath said. “We would like to see how we can help, but the lack of information makes it difficult to do so.”





ZiggysFryBoy

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Re: Vaccine/Antibody updates
« Reply #299 on: September 15, 2020, 03:41:40 PM »
NIH closely evaluating the adverse event in the Astra Zeneca trial...but A-Z is not being very forthcoming. Glad to see NIH is pressing them on this serious event, and disappointed that A-Z is being so evasive. I hope NIH keeps the pressure on, and only gives the green light if and when satisfactory answers are provided.

NIH is ‘very concerned’ about serious side effect in coronavirus vaccine trial

https://www.latimes.com/science/story/2020-09-15/nih-concerned-side-effect-in-astrazeneca-coronavirus-vaccine-trial

“The highest levels of NIH are very concerned,” said Dr. Avindra Nath, intramural clinical director and a leader of viral research at the National Institute for Neurological Disorders and Stroke, a division of the NIH. “Everyone’s hopes are on a vaccine, and if you have a major complication the whole thing could get derailed.”

A great deal of uncertainty remains about what happened to the unnamed patient. AstraZeneca said the trial volunteer recovered from a severe inflammation of the spinal cord and is no longer hospitalized.

Nath and another neurologist said they understood that the patient was afflicted with transverse myelitis, though the company has not confirmed this. Transverse myelitis produces symptoms involving inflammation along the spinal cord that can cause pain, muscle weakness and paralysis.

AstraZeneca “need to be more forthcoming with a potential complication of a vaccine which will eventually be given to millions of people,” Nath said. “We would like to see how we can help, but the lack of information makes it difficult to do so.”


Just release it and then run 60 second ads with all of the side effects.   They'll be fine, as they have people looking at the sky, running fingers through flowers, roller skating or drinking ice tea.  Muzak is also necessary.

 

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