Vaccine/Antibody updates

[Frenns Liquor Depot]

I dont know what this means for safety/efficacy re-trials or how quickly the production line can be changed, but AZ already working on a tweak to the vaccine to cover mutations and will be read in 6 weeks. 

Additionally, the SA trial that necessitated the pause could not assess protection against severe COVID or death because the trial skewed too small and too young.  Seems like an odd move by the government to shut it down based on that info.

https://www.cnbc.com/2021/02/08/astrazeneca-races-to-adapt-covid-vaccine-as-south-africa-halts-rollout.html

Clearly we are all getting boosters for a foreseeable amount of time....so knowing that, all i need to know to take a vaccine is that it offers some protection.

PS it seems like AZ has not had a clear cut trial yet.  What a failure versus some of the others. 

[GooooMarquette]

I dont know what this means for safety/efficacy re-trials or how quickly the production line can be changed, but AZ already working on a tweak to the vaccine to cover mutations and will be read in 6 weeks. 

Additionally, the SA trial that necessitated the pause could not assess protection against severe COVID or death because the trial skewed too small and too young.  Seems like an odd move by the government to shut it down based on that info.

https://www.cnbc.com/2021/02/08/astrazeneca-races-to-adapt-covid-vaccine-as-south-africa-halts-rollout.html

Clearly we are all getting boosters for a foreseeable amount of time....so knowing that, all i need to know to take a vaccine is that it offers some protection.

PS it seems like AZ has not had a clear cut trial yet.  What a failure versus some of the others.

Interesting, and disappointing.

Regarding the question of safety and efficacy trials for vaccines that are changed to deal with variants: for 'traditional' vaccines using platforms that have long safety profiles (like the annual flu shot), regulators don't require much. That will probably be the case for the AZ vaccine, which uses an adenovirus platform. For the new are mRNA vaccines like Pfizer and Moderna, the question is still unresolved as far as I know.

[Frenns Liquor Depot]

I've always found Gottlieb to be pretty accurate in his assessments.  It would be great if his prediction on the point where supply > demand is right. 

https://twitter.com/scottgottliebmd/status/1359532849553158145?s=21

[GooooMarquette]

I've always found Gottlieb to be pretty accurate in his assessments.  It would be great if his prediction on the point where supply > demand is right. 

https://twitter.com/scottgottliebmd/status/1359532849553158145?s=21

Yes, it would be fabulous if we get to that point by April. My personal prediction is that I'll get it in June because I'm near the end of the priority line...but I would love to be wrong.

[Warrior2008]

https://www.nytimes.com/2021/02/10/us/houston-doctor-fired-covid-vaccine.html?action=click&module=Top%20Stories&pgtype=Homepage

This is without a doubt the dumbest thing I've read regarding the vaccine rollout and a perfect example of bureaucratic incompetence and a DA who is a moron.  Everyone agrees with following the priority groups and its pretty clear this doctor tried to do that, but given how the vaccine is distributed, there are real situations where vaccine is leftover.  The vaccine comes in large vials where you get 10 or even 11 doses in each vial.  Once the seal is broken, the vaccine needs to be used asap(6 hours).  Anyone arguing for throwing good vaccine away fails to miss the very simple point that vaccines only work when in someone's arm.  Obviously you would want that vaccine in a 1a or 1b individual, but if that's not possible for whatever reason, then anyone is better than no one. 

Its not about fairness or equity when the alternative is throwing away perfectly good vaccine, but being resourceful so it doesn't take double the amount of vaccine to vaccinate one person.

[Warriors4ever]

It's doubtful he gets indicted, and no way he is getting convicted. The district attorney is an idiot. His superiors should have threatened to resign en masse.

[Billy Hoyle]

https://www.nytimes.com/2021/02/10/us/houston-doctor-fired-covid-vaccine.html?action=click&module=Top%20Stories&pgtype=Homepage

This is without a doubt the dumbest thing I've read regarding the vaccine rollout and a perfect example of bureaucratic incompetence and a DA who is a moron.  Everyone agrees with following the priority groups and its pretty clear this doctor tried to do that, but given how the vaccine is distributed, there are real situations where vaccine is leftover.  The vaccine comes in large vials where you get 10 or even 11 doses in each vial.  Once the seal is broken, the vaccine needs to be used asap(6 hours).  Anyone arguing for throwing good vaccine away fails to miss the very simple point that vaccines only work when in someone's arm.  Obviously you would want that vaccine in a 1a or 1b individual, but if that's not possible for whatever reason, then anyone is better than no one. 

Its not about fairness or equity when the alternative is throwing away perfectly good vaccine, but being resourceful so it doesn't take double the amount of vaccine to vaccinate one person.

It should be about that, but...

[Sir Lawrence]

Just got my second Shingles vax shot, and was informed that the advice is to not get the COVID vax for two weeks.  Shouldn't be an issue, unfortunately. 

[Hards Alumni]

Just got my second Shingles vax shot, and was informed that the advice is to not get the COVID vax for two weeks.  Shouldn't be an issue, unfortunately.

Yeah its one of the questions they ask you when you register for your covid vax.

[Jockey]

Biden has secured enough vaccine to vaccinate everyone by July. Of 2020!

This has been done in 3 weeks with almost nothing in place when he took over.

How many of the almost 500,000 deaths are now on one incompetent fool? And those who voted for and supported him?

[4everwarriors]

Yeah, dat fookin' fool only got da vaccine in motion, and in warp speed, while in office so C'mon Man Joe could be the hero and place an order, with one swift stroke of his pen. Oh, how easy, but we won't go there, hey?

[wadesworld]

Yeah, dat fookin' fool only got da vaccine in motion, and in warp speed, while in office so C'mon Man Joe could be the hero and place an order, with one swift stroke of his pen. Oh, how easy, but we won't go there, hey?

I'm just happy he remembers what a pen is and how to use it at his advanced age, hey doc?

[Galway Eagle]

Yeah, dat fookin' fool only got da vaccine in motion, and in warp speed, while in office so C'mon Man Joe could be the hero and place an order, with one swift stroke of his pen. Oh, how easy, but we won't go there, hey?

Didn't Pfizer only take funds from the German version of warp speed?

[4everwarriors]

For now, until the Party ushers him outta office. Doubt folks in the energy industry are thrilled with his penmanship, hey?

[The Sultan]

Yeah, dat fookin' fool only got da vaccine in motion, and in warp speed, while in office so C'mon Man Joe could be the hero and place an order, with one swift stroke of his pen. Oh, how easy, but we won't go there, hey?

Yep.  He managed to do one thing right in 10 months.

Best President of your lifetime ai'na?

[forgetful]

Didn't Pfizer only take funds from the German version of warp speed?

Yes, and because they did not accept funds from warp speed, Trump's government refused to give them any priorities for essential reagents, and refused to give them priority for essential infrastructure/equipment, delaying production.

Biden immediately undid that, use the DPA to secure reagents and equipment, so that we could likely 1/2 the time needed to vaccinate everyone.

[Galway Eagle]

Yes, and because they did not accept funds from warp speed, Trump's government refused to give them any priorities for essential reagents, and refused to give them priority for essential infrastructure/equipment, delaying production.

Biden immediately undid that, use the DPA to secure reagents and equipment, so that we could likely 1/2 the time needed to vaccinate everyone.

This makes sense. Was wondering why my question was ignored.

[TSmith34, Inc.]

How many of the almost 500,000 deaths are now on one incompetent fool?

False!

I think you ae overlooking the substantial help from Secretary Of Failure Jared.

[🏀]

For now, until the Party ushers him outta office. Doubt folks in the energy industry are thrilled with his penmanship, hey?

You want to compare the energy industry versus all the industries Trump left empty promises with?

Blood on your hands, but keep going.

[Frenns Liquor Depot]

Yep.  He managed to do one thing right in 10 months.

Best President of your lifetime ai'na?

Warp speed was great and accelerated the trials.  My question is that we put up all that money up front to get those companies to manufacture immediately regardless of the outcome of the trial -- doesn't seem to have worked on that front.   JNJ in particular.

[GooooMarquette]

F.D.A. Agrees Moderna Can Increase Vaccine Supply in Each Vial

https://www.nytimes.com/2021/02/12/us/moderna-coronavirus-vaccine-supply.html?action=click&module=Top%20Stories&pgtype=Homepage

A good move, but it will likely take Moderna until April to retool production to accommodate the change. Seems like this is something the company and regulators should have discussed months ago.

[tower912]

That would have required caring, planning, and coordination.

[mu_hilltopper]

Just got my second Shingles vax shot, and was informed that the advice is to not get the COVID vax for two weeks.  Shouldn't be an issue, unfortunately. 

I was offered the Shingles vax a month ago, and declined for this very reason.  I can wait a year, hopefully.

[BM1090]

The past four days, 7.6 million doses have been administered in the US.

[Frenns Liquor Depot]

The past four days, 7.6 million doses have been administered in the US.

This is great news and with the supply increases on the horizon, should really open up the floodgates.   Maybe I should temper my enthusiasm, but I actually believe I may get a chance at vaccine in April.