Vaccine/Antibody updates

[GooooMarquette]

Can We Do Twice as Many Vaccinations as We Thought?

https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html?action=click&module=Opinion&pgtype=Homepage

Interesting opinion piece in the NYT. It proposes a single-dose trial among young, healthy frontline workers to see if a single dose provides sufficient protection.

But to me, the more tantalizing answer actually lies buried in the article, almost as an afterthought: There is no 'magic timeframe' for giving the second dose, and we might get the same ~95% efficacy if we lengthen the time to the booster shot. The 21-day and 28-day timeframes in the Pfizer and Moderna trials were just guesses...and likely chosen so they could finish the studies more quickly. If we changed those timeframes, it's quite plausible the protection for the first shot would still exist for a few months...thus freeing up more shots for people to get their initial vaccinations now.

Not the most scientific approach, and I seriously doubt they'll change anything at this point, but an interesting possibility given the extreme situation we're living through.

[forgetful]

Can We Do Twice as Many Vaccinations as We Thought?

https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html?action=click&module=Opinion&pgtype=Homepage

Interesting opinion piece in the NYT. It proposes a single-dose trial among young, healthy frontline workers to see if a single dose provides sufficient protection.

But to me, the more tantalizing answer actually lies buried in the article, almost as an afterthought: There is no 'magic timeframe' for giving the second dose, and we might get the same ~95% efficacy if we lengthen the time to the booster shot. The 21-day and 28-day timeframes in the Pfizer and Moderna trials were just guesses...and likely chosen so they could finish the studies more quickly. If we changed those timeframes, it's quite plausible the protection for the first shot would still exist for a few months...thus freeing up more shots for people to get their initial vaccinations now.

Not the most scientific approach, and I seriously doubt they'll change anything at this point, but an interesting possibility given the extreme situation we're living through.

I was thinking of something similar to this. A couple ways to get to a "herd" immunity faster.

1. Estimates say that the actual number the have been infected is closer to 60M (I don't think it is nearly this high, but the fact remains that a lot have been infected and don't know). Those already have some level of immunity. If we could screen those to be vaccinated with rapid antibody tests first, and only give vaccines to those without antibodies we could vaccinate more faster.

2. For those that are young, and otherwise healthy. Give 1 dose. I believe the Moderna vaccine proved to be ~70% effective with a single dose. Prioritize the Moderna vaccine to that group.

3. Possibly, in general give everyone 1-dose. The actual studies showed 50-70% efficacy after one dose, and decreased severity in general. Although not perfect, this will drastically decrease the hospital burden, and save more lives. Possibly only give 2-dose regimes to nursing home/high-risk elderly.

4. Quit prioritizing work-from-home medical staff.

[Frenns Liquor Depot]

If it were me, I would just try to execute the plan rather than getting creative.  We have a hard enough time with the simple things.

[tower912]

A potential kick in the groin for Michiganians.   

https://www.mlive.com/public-interest/2020/12/pfas-exposure-may-reduce-covid-19-vaccine-potency-experts-warn.html


PFAS exposure may reduce the effectiveness of the vaccine.   

[Its DJOver]

https://twitter.com/Emaperidol/status/1339224471731843073

My boyfriend got his covid vaccine yesterday and I can tell you the most prominent side effect is the inability to shut up about getting the covid vaccine

[Hards Alumni]

A potential kick in the groin for Michiganians.   

https://www.mlive.com/public-interest/2020/12/pfas-exposure-may-reduce-covid-19-vaccine-potency-experts-warn.html


PFAS exposure may reduce the effectiveness of the vaccine.   

Great, we have a bunch of them here too.

[jesmu84]

https://twitter.com/SethAbramson/status/1339704802964615168?s=19

[GooooMarquette]

I was thinking of something similar to this. A couple ways to get to a "herd" immunity faster.

1. Estimates say that the actual number the have been infected is closer to 60M (I don't think it is nearly this high, but the fact remains that a lot have been infected and don't know). Those already have some level of immunity. If we could screen those to be vaccinated with rapid antibody tests first, and only give vaccines to those without antibodies we could vaccinate more faster.

2. For those that are young, and otherwise healthy. Give 1 dose. I believe the Moderna vaccine proved to be ~70% effective with a single dose. Prioritize the Moderna vaccine to that group.

3. Possibly, in general give everyone 1-dose. The actual studies showed 50-70% efficacy after one dose, and decreased severity in general. Although not perfect, this will drastically decrease the hospital burden, and save more lives. Possibly only give 2-dose regimes to nursing home/high-risk elderly.

4. Quit prioritizing work-from-home medical staff.

The other alternative: Start with one dose until everybody who wants one gets it...then move on to the second dose, whether it's three months or a year later. It gets one shot in everybody's arm faster, but doesn't eliminate the added boost from the second shot.

[MUDPT]

Can We Do Twice as Many Vaccinations as We Thought?

https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html?action=click&module=Opinion&pgtype=Homepage

Interesting opinion piece in the NYT. It proposes a single-dose trial among young, healthy frontline workers to see if a single dose provides sufficient protection.

But to me, the more tantalizing answer actually lies buried in the article, almost as an afterthought: There is no 'magic timeframe' for giving the second dose, and we might get the same ~95% efficacy if we lengthen the time to the booster shot. The 21-day and 28-day timeframes in the Pfizer and Moderna trials were just guesses...and likely chosen so they could finish the studies more quickly. If we changed those timeframes, it's quite plausible the protection for the first shot would still exist for a few months...thus freeing up more shots for people to get their initial vaccinations now.

Not the most scientific approach, and I seriously doubt they'll change anything at this point, but an interesting possibility given the extreme situation we're living through.

The confidence interval on the low end of 1 dose of Pfizer was 28%? effective. Too low.

[MUDPT]

I work in Madison, at one of the three main hospitals. Hospital A is affiliated with the university who thinks they are good at basketball. Hospital B is us, who are "partners" of hospital A. Hospital C is down the street. Madison got vaccines on Tuesday.

Hospital A is vaccinating their top two tiers.
Hospital C is vaccinating every employee.
Hospital B has no vaccines and no idea when they are getting them.

Hospital A's Covid population has been around 65-70.
Hospital B's Covid population has been around 50-60 (a majority of which have come from Hospital A).
Hospital C's Covid population has been around 30-40.

We were told Hospital B didn't get initial vaccines because they didn't have as many employees.

AMERICA!!!

[GooooMarquette]

The confidence interval on the low end of 1 dose of Pfizer was 28%? effective. Too low.

Agreed. That's why I think we should stick with 2 doses, but just split them a little further apart. The difference between 21 days and 3 months is likely to be inconsequential, and would help us to return to a semblance of normalcy more quickly.

[Jockey]

https://twitter.com/SethAbramson/status/1339704802964615168?s=19

As I have said here often, cruelty IS the point.

By withholding the vaccine, they are choosing to kill people. Sounds like murder to me.

[4everwarriors]

I work in Madison, at one of the three main hospitals. Hospital A is affiliated with the university who thinks they are good at basketball. Hospital B is us, who are "partners" of hospital A. Hospital C is down the street. Madison got vaccines on Tuesday.

Hospital A is vaccinating their top two tiers.
Hospital C is vaccinating every employee.
Hospital B has no vaccines and no idea when they are getting them.

Hospital A's Covid population has been around 65-70.
Hospital B's Covid population has been around 50-60 (a majority of which have come from Hospital A).
Hospital C's Covid population has been around 30-40.

We were told Hospital B didn't get initial vaccines because they didn't have as many employees.

AMERICA!!!

Eye'd recommend quittin' B and gettin' a gig @ A. America, aina?

[Hards Alumni]

I work in Madison, at one of the three main hospitals. Hospital A is affiliated with the university who thinks they are good at basketball. Hospital B is us, who are "partners" of hospital A. Hospital C is down the street. Madison got vaccines on Tuesday.

Hospital A is vaccinating their top two tiers.
Hospital C is vaccinating every employee.
Hospital B has no vaccines and no idea when they are getting them.

Hospital A's Covid population has been around 65-70.
Hospital B's Covid population has been around 50-60 (a majority of which have come from Hospital A).
Hospital C's Covid population has been around 30-40.

We were told Hospital B didn't get initial vaccines because they didn't have as many employees.

AMERICA!!!

A = UW Hospital
B = Meriter
C = SSM Health

Pretty obvious.

[jesmu84]

Just received mine. Pfizer.

[GooooMarquette]

Just received mine. Pfizer.

I think you're the first here. Hope it goes uneventfully.

[4everwarriors]

Eye'm jellus. If ya score sum xtra Pfizer or Moderna, help a bro out, hey?

[GooooMarquette]

Eye'm jellus. If ya score sum xtra Pfizer or Moderna, help a bro out, hey?

Even though you aren't a first responder or ER or ICU provider, it would seem a dentist oughta be pretty high on the list. Any idea what level of priority you have?

[4everwarriors]

1A in Wisconsin, hey?

[GooooMarquette]

1A in Wisconsin, hey?

👍

Hopefully the line moves quickly.

[GooooMarquette]

FDA just officially approved Moderna vaccine for emergency use.

Facilities should begin receiving doses by Monday.

[MUDPT]

A = UW Hospital
B = Meriter
C = SSM Health

Pretty obvious.

Bingo. A keeps sending positives to B, where no vaccinated workers work.

[Warriors4ever]

https://www.cnn.com/2020/12/19/us/covid-vaccine-wealthy-california-patients/index.html

And then there's these entitled people.

[MU82]

Pence wasn't listening to Tucker Carlson, who told his viewing audience to not trust the vaccines.

From today's AP article ...

Pence didn't flinch during the quick prick, nor did his wife, Karen ...

... who is used to her husband's quick prick.

[Frenns Liquor Depot]

vaccine drive immunity on top of illness driven immunity topic. 

https://twitter.com/erictopol/status/1339998897498775552?s=21