Hydroxychloroquinine updates (and other potential treatments)

[GooooMarquette]

ICAM.   Out of Florida.   Logic tracks.  Common medicines in combination.

Makes sense. Hope it proves successful in larger-scale use.

[jesmu84]

Why no use of (or at least no mention of) Hydroxy on POTUS?

[Galway Eagle]

Why no use of (or at least no mention of) Hydroxy on POTUS?

Because he's taking it already to prevent Covid. Obviously

[MU82]

Eli Lilly has to pause its antibody treatment trials because subjects are getting sick.

https://www.nytimes.com/live/2020/10/13/world/coronavirus-covid?campaign_id=60&emc=edit_na_20201013&instance_id=0&nl=breaking-news&ref=headline&regi_id=108420427&segment_id=40859&user_id=d36dcf821462fdd16ec3636710a855fa#eli-lilly-antibody-trial-is-paused-because-of-potential-safety-concerns

[Galway Eagle]

Eli Lilly has to pause its antibody treatment trials because subjects are getting sick.

https://www.nytimes.com/live/2020/10/13/world/coronavirus-covid?campaign_id=60&emc=edit_na_20201013&instance_id=0&nl=breaking-news&ref=headline&regi_id=108420427&segment_id=40859&user_id=d36dcf821462fdd16ec3636710a855fa#eli-lilly-antibody-trial-is-paused-because-of-potential-safety-concerns

Well that's 2 of ours paused. At least the British vaccine is back on.

[GooooMarquette]

Well that's 2 of ours paused. At least the British vaccine is back on.

I'm not sure which 2 you're referring to...but if you are including phase 3 vaccine studies, there are 3 studies currently paused in the US:

* this Eli Lilly monoclonal antibody study
* the AstraZeneca vaccine study (the British one; open in UK, but not in US)
* the J & J vaccine study

[Galway Eagle]

I'm not sure which 2 you're referring to...but if you are including phase 3 vaccine studies, there are 3 studies currently paused in the US:

* this Eli Lilly monoclonal antibody study
* the AstraZeneca vaccine study (the British one; open in UK, but not in US)
* the J & J vaccine study

JJ and Lilly were the ones I was referring to being paused. AstraZeneca was the one I was referring to being back open after that hiccup a few weeks ago

[GooooMarquette]

JJ and Lilly were the ones I was referring to being paused. AstraZeneca was the one I was referring to being back open after that hiccup a few weeks ago

True, but it is still on hold in the US. Given that large numbers of subjects were expected to be enrolled here, I'd call that more than a 'hiccup.' And there are previously enrolled subjects in limbo:

https://www.statnews.com/2020/10/06/astrazeneca-covid19-second-dose-trial-vaccine/

Kinda makes you wonder if they'll even be able to use the US data at all, given the unexpectedly long lag between doses.

[rocket surgeon]

Eli Lilly has to pause its antibody treatment trials because subjects are getting sick.

https://www.nytimes.com/live/2020/10/13/world/coronavirus-covid?campaign_id=60&emc=edit_na_20201013&instance_id=0&nl=breaking-news&ref=headline&regi_id=108420427&segment_id=40859&user_id=d36dcf821462fdd16ec3636710a855fa#eli-lilly-antibody-trial-is-paused-because-of-potential-safety-concerns

  and you can hardly contain your excitement...good on eli to put the people and safety before anything else.  ya got anything on companies moving positively and safely forward?  buzz kills suck, eyn'a?

[GooooMarquette]

  and you can hardly contain your excitement...good on eli to put the people and safety before anything else.  ya got anything on companies moving positively and safely forward?  buzz kills suck, eyn'a?

Perhaps you are not familiar with how clinical trials work, but we almost never know about trials that are going “positively“ until they are done and the data has been analyzed. In fact, study doctors are usually contractually prohibited from imputing positive results to study drugs during the course of the study. Because of that, the public only hears about studies that need to be halted or terminated because of adverse events.

Typically, all the public will know is that the study is proceeding. Nothing more, nothing less.

No classes about clinical research in dental school?

[MU82]

  and you can hardly contain your excitement...good on eli to put the people and safety before anything else.  ya got anything on companies moving positively and safely forward?  buzz kills suck, eyn'a?

what the eff you talkin' about?

you know, i try to stop by just to see what's happening, but these are the types of posts that make this board tough to read.  come on rock, get to a meeting or something

[TSmith34, Inc.]

No classes about clinical research in dental school?

"Healthcare professional"

[shoothoops]

https://twitter.com/FinancialTimes/status/1316822064427339776?s=19

"World Health Organization clinical trial finds Remdesivir has no substantial effect on a patient's chance for survival."

[GooooMarquette]

https://twitter.com/FinancialTimes/status/1316822064427339776?s=19

"World Health Organization clinical trial finds Remdes ivir has no substantial effect on a patient's chance for survival."

Well that’s disturbing. So at this point we are basically using immune system boosters and steroids.

Maybe other trials will refute this. Still, not a happy outcome.

[forgetful]

Well that’s disturbing. So at this point we are basically using immune system boosters and steroids.

Maybe other trials will refute this. Still, not a happy outcome.

Don't forget Regeneron. I think that is still by far the best option. Too bad we didn't invest more heavily in it right away.

[TSmith34, Inc.]

https://twitter.com/FinancialTimes/status/1316822064427339776?s=19

"World Health Organization clinical trial finds Remdesivir has no substantial effect on a patient's chance for survival."

Errrr, wasn't that the finding initially as well? That chances of survival did not improve with the drug, but that those that did survive recovered on average 4 days more quickly?

[GooooMarquette]

Don't forget Regeneron. I think that is still by far the best option. Too bad we didn't invest more heavily in it right away.

Totally agree. I did not mention Regeneron’s monoclonal antibodies because they are not yet approved, but you are right - it holds great promise.

[rocket surgeon]

Perhaps you are not familiar with how clinical trials work, but we almost never know about trials that are going “positively“ until they are done and the data has been analyzed. In fact, study doctors are usually contractually prohibited from imputing positive results to study drugs during the course of the study. Because of that, the public only hears about studies that need to be halted or terminated because of adverse events.

Typically, all the public will know is that the study is proceeding. Nothing more, nothing less.

No classes about clinical research in dental school?

  why yes GM, there are many classes that cite clinical research as their method to prove or disprove many things, materials, methods, drugs, etc used in our field.  i can read the reports as well as anyone, but you missed my point.   no need to question my understanding of the scientific methods used here, or was that just a "how many clinical research studies have you had an active participation in jab. 

   there are some here that don't know "jack" about how these things work and the fact that situational efficacies must be taken into effect depending on the "risk-reward".  i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all   

[Frenns Liquor Depot]

i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all

All this from a link being posted with the topic included?

If you’re projecting based on who posted the article fine, but at least be honest about it.

[Hards Alumni]

  why yes GM, there are many classes that cite clinical research as their method to prove or disprove many things, materials, methods, drugs, etc used in our field.  i can read the reports as well as anyone, but you missed my point.   no need to question my understanding of the scientific methods used here, or was that just a "how many clinical research studies have you had an active participation in jab. 

   there are some here that don't know "jack" about how these things work and the fact that situational efficacies must be taken into effect depending on the "risk-reward".  i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all

I worked at a GMP lab for a few years, so I'd say I know jack.  Malarkey.

[shoothoops]

Pfizer:

https://twitter.com/WSJ/status/1317046528637243393?s=19

Straight from the Pfizer CEO:

https://twitter.com/AlbertBourla/status/1317045723540656128?s=19

[tower912]

  why yes GM, there are many classes that cite clinical research as their method to prove or disprove many things, materials, methods, drugs, etc used in our field.  i can read the reports as well as anyone, but you missed my point.   no need to question my understanding of the scientific methods used here, or was that just a "how many clinical research studies have you had an active participation in jab. 

   there are some here that don't know "jack" about how these things work and the fact that situational efficacies must be taken into effect depending on the "risk-reward".  i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all

Bullsh!t.

[GooooMarquette]

  why yes GM, there are many classes that cite clinical research as their method to prove or disprove many things, materials, methods, drugs, etc used in our field.  i can read the reports as well as anyone, but you missed my point.   no need to question my understanding of the scientific methods used here, or was that just a "how many clinical research studies have you had an active participation in jab. 

   there are some here that don't know "jack" about how these things work and the fact that situational efficacies must be taken into effect depending on the "risk-reward".  i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all

I don't know of anyone who is 'rooting for failure' here. We are all susceptible to the virus, and we are all sick of wearing masks, socially distancing, and balancing the risks and benefits of visiting with friends and family.  And we (or family or friends) all could get the virus tomorrow...so rooting for delays in treatment is inherently against our interests.

And my key point stands as the simple, straightforward answer to the comment you posed initially: In terms of public information, the clinical trial process is set up so that there will always be more news available about studies being halted for safety issues than there is about studies that are moving along smoothly. Your initial comment seemed to indicate confusion about that topic - sorry if I took it at face value.

[MU82]

   there are some here that don't know "jack" about how these things work and the fact that situational efficacies must be taken into effect depending on the "risk-reward".  i sense a rooting for the failure of the process here for a few more weeks anyway and find it disgusting as there is a fine line between a little diarrhea and quelling a widespread virus for the good of all

you know, i try to stop by just to see what's happening, but these are the types of posts that make this board tough to read.  come on rock, get to a meeting or something

[Plaque Lives Matter!]

Pfizer:

https://twitter.com/WSJ/status/1317046528637243393?s=19

Straight from the Pfizer CEO:

https://twitter.com/AlbertBourla/status/1317045723540656128?s=19

That's exciting news. Obviously widespread safety is the biggest concern but it is one of the hurdles.