Almost all of these are not for kids and cover a really wide variety of topics. Obviously, the guests play a large role but the formats for most of these have lead me to additional content and podcasts.
Comedy
Kill Tony - Open Mic format hosted live from The Comedy Store by Tony Hinchcliffe
Legion of Skanks - Louis J Gomez, Big Jay Okerson and Dave Smith
The Adam and Dr. Drew Show - great if you listened to Loveline back in the day
The Church of What's Happening - Joey Coco Diaz and Lee Syatt
Fitzdog Radio
Norm Macdonald Live - similar to his new show on Netflix
Bertcast - I am the machine
The Chip Chipperson Podacast - Maybe Jim Norton's best character
Jeremiah Wonders - Jeremiah Watkins hosts w/ great guests
The Jeselnik & Rosenthal Vanity Project - not quite as good as the Rosenthal & Jeselnik Vanity Project (RJVP) from 2 years ago, but still pretty funny take on the NFL
Pop Culture
The Adam Carolla Show - Interesting guests and fun for fans that used to listen to Loveline
The Rubin Report
The Bret Easton Ellis Podcast - Now on Patreon
The Joe Rogan Experience
Politics
Part of the Problem - Dave Smith covers Anarcho Capitalist & Libertarian ideas w/ Robbie the fire Bernstein
The Tom Woods Show - Libertarian topics
Reasonable Doubt - Adam Carolla, Mark Garagos take on legal topics, pop culture and America today
Unregistered with Thaddeus Russel - Anarcho topics with different guests and perspectives
Reason Podcast - Libertarian topics
Lions of Liberty - Libertarian topics - 3 different episodes per week with 3 different hosts. They take turns and offer different perspectives on new topics
Jim Goad's Group Hug